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KMID : 0384119930130020197
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Korean Journal of Clinical Pathology
1993 Volume.13 No. 2 p.197 ~ p.210
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Histological Classification of Chronic Myelogenous Leukemia: Clinicopathologic Correlation and Prognostic Significance
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이남용
박성섭/조한익/김상인/김병국/박선양/김현
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Abstract
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We classified chronic myelogenous leukemia according to the bone marrow histology and evaluated its prognostic significance. Marrow biopsy sections of 108 patients, who were diagnosed as chronic myelogenous leukemia in chronic phase at Seoul
National
University Hospital from 1980 to 1991, were classified into two histological types; granulocytic type and granulo-/megakaryocytic type(mixed type). The number of cases of granulocytic type and mixed type were 36(33.3%) and 72(67.7%),
respectively.
Mixed
type showed higher counts of peripheral leukocyte(p<0.05) and platelet(p<0.001), and higher percentages of peripheral blasts(p<0.001), marrow blasts(p<0.001) and marrow bsophils(p<0.001) than granulocytic type at the time of initial biopsy.
Thrombocytopenia was encountered more frequently in granulocytic type than in mixed type(p<0.001). Granulocytic type showed a tendency to progress into blast crisis, while mixed type into myelofibrosis. The interval to the onset of blast
crisis(duration
of chronic phase) and suvival time were shorter in granulocytic type than in mixed type It is concluded that histological classification of bone marrow is important diagnostic and prognostic parameter in CML, and should be used for the prognostic
evaluation together with other clinical and hematological data.
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KEYWORD
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